- Edward Teller -

“The science of today is the technology of tomorrow”


Journal Publications
  1. M. Gori, S.M. Giannitelli, M.Torre, P. Mozetic, F. Abbruzzese, M. Trombetta, E. Traversa, L. Moroni, A. Rainer. Biofabrication of hepatic constructs by 3D bioprinting of a cell-laden thermogel: an effective tool to assess drug-induced hepatotoxic response. Adv Healthcare Mater (2020). doi: 10.1002/adhm.202001163.

  2. S. Pagliari, V. Vinarsky, F. Martino, A.R. Perestrelo, J. Oliver-De La Cruz, G. Caluori, J. Vrbsky, P. Mozetic, A. Pompeiano, A. Zancla, S.G. Ranjani, P. Skladal, D. Kytyr, Z. Zdráhal, G. Grassi, M. Sampaolesi, A. Rainer, G. Forte. YAP–TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification. Cell Death & Differentiation (2020). doi: 10.1038/s41418-020-00643-5.

  3. A.R. Perestrelo, A.C. Silva, J. Oliver-De La Cruz, F. Martino, V. Horvath, G. Caluori, O. Polanský, V. Vinarsky, G. Azzato, G. de Marco, V. Zampachova, P. Skladal, S. Pagliari, A. Rainer, P. Pinto-do-Ó, A. Caravella, K. Koci, D.S. Nascimento, G. Forte. Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart. Circulation Research (2020). doi: 10.1161/CIRCRESAHA.120.317685.

  4. M. Gori, S.M. Giannitelli, A. Zancla, P. Mozetic, M. Trombetta, A. Rainer. Quercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD-on-a-chip study. Biotechnology and Bioengineering. (2020). doi: 10.1002/bit.27557

  5. E. Mauri, A. Salvati, A. Cataldo, P. Mozetic, F. Basoli, F. Abbruzzese, M. Trombetta, S. Bellucci, A. Rainer. Graphene-laden hydrogels: a strategy for thermally triggered drug delivery. Mater Sci Eng C. (2020). doi: 10.1016/j.msec.2020.111353. In press.

  6. S. Scarpino, S. Taccogna, G. Pepe, E. Papini, M. D’Angelo, F. Cascone, D. Nicoletti, R. Guglielmi, A. Palermo, M. Trombetta, A. Rainer, C. Taffon, A. Crescenzi. Morphological and molecular assessment in thyroid cytology using cell-capturing scaffolds. Horm Metabol Res. (2020) doi: 10.1055/a-1157- 6419. Epub ahead of print

  7. M. Gori, A. Altomare, S. Cocca, E. Solida, M. Ribolsi, S. Carotti, A. Rainer, M. Francesconi, S. Morini, M. Cicala, M.P.L. Guarino, Palmitic acid affects intestinal epithelial barrier integrity and permeability in vitro, Antioxidants 9 (2020) 417. doi:10.3390/antiox9050417.

  8. S. Lorenzetti, G. Aquilina, F. Caloni, E.M. Coccia, P. Cozzini, G. Cruciani, A. Fouassier, A. Gissi, L. Goracci, T. Heinonen, P. Hubert, F. Madia, F. Nevelli, A. Rainer, C. Rovida, A. Vitale, I. De Angelis. Non animal methodologies (NAMs): Research, testing, assessment and applications - ecopa Symposium 2019. ALTEX 37(2) (2020) 317. doi:10.14573/altex.2003041

  9. E. Mauri, A. Rossetti, P. Mozetic, C. Schiavon, A. Sacchetti, A. Rainer, F. Rossi, Ester coupling of ibuprofen in hydrogel matrix: a facile one-step strategy for controlled anti-inflammatory drug release. Eur J Pharm Biopharm 146 (2020) 143. doi:10.1016/j.ejpb.2019.11.002

  10. E. Mauri, P. Veglianese, S. Papa, A. Rossetti, M. De Paola, A. Mariani, Z. Posel, P. Posocco, A. Sacchetti, F. Rossi, Effects of primary amine-based coatings on microglia internalization of nanogels, Colloids Surf B - in press. doi:10.1016/j.colsurfb.2019.110574

  11. E. Mauri, D. Naso, A. Rossetti, E. Borghi, E. Ottaviano E., G. Griffini, M. Masi, A. Sacchetti, F. Rossi, Design of polymer-based antimicrobial hydrogels through physico-chemical transition, Mater Sci Eng C 103 (2019), 109791. doi:10.1016/j.msec.2019.109791

  12. E. Nocita, A. Del Giovane, M. Tiberi, L. Boccuni, D. Fiorelli, C. Sposato, E. Romano, F. Basoli, M. Trombetta, A. Rainer, E. Traversa, A. Ragnini-Wilson. EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP. Cells. 8 (2019) 844. doi: 10.3390/cells8080844.

  13. E. Mauri, G. Perale, F. Rossi, Nanogel functionalization: a versatile approach to meet the challenges of drug and gene delivery, ACS Appl Nano Mater 1 (2018), 6525-6541. doi:10.1021/acsanm.8b01686

  14. M. Costantini, J. Guzowski P.J. Żuk, P. Mozetic, S. De Panfilis, J. Jaroszewicz, et al. Electric Field Assisted Microfluidic Platform for Generation of Tailorable Porous Microbeads as Cell Carriers for Tissue Engineering, Adv. Funct. Mater. (2018). doi:10.1002/adfm.201800874.

  15. F. R. Bertani, P. Mozetic, M. Fioramonti, M. Iuliani, G. Ribelli, F. Pantano, D. Santini, G. Tonini, M. Trombetta, L. Businaro, S. Selci, A. Rainer, Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis, Sci. Rep.,7 (2017) 8965. doi:10.1038/s41598-017-08121-8. 

  16. A. Gizzi, S.M. Giannitelli, M. Trombetta, C. Cherubini, S. Filippi, A. De Ninno, L. Businaro, A. Gerardino, A. Rainer, Computationally Informed Design of a Multi-Axial Actuated Microfluidic Chip Device, Sci. Rep. 7 (2017) 5489.  

  17. S. Testa, M. Costantini, E. Fornetti, S. Bernardini, M. Trombetta, D. Seliktar, et al., Combination of biochemical and mechanical cues for tendon tissue engineering, J. Cell. Mol. Med. (2017). doi:10.1111/jcmm.13186.

  18. C. Spadaccio, F. Nappi, F. De Marco, P. Sedati, C. Taffon, A. Nenna, et al., Implantation of a Poly-L-Lactide GCSF-Functionalized Scaffold in a Model of Chronic Myocardial Infarction, J. Cardiovasc. Transl. Res. 10 (2017) 47–65. doi:10.1007/s12265-016-9718-9.

  19. P. Mozetic, S.M. Giannitelli, M. Gori, M. Trombetta, A. Rainer, Engineering muscle cell alignment through 3D bioprinting, J. Biomed. Mater. Res. A. (2017). doi:10.1002/jbm.a.36117.

  20. V. Lucarini, C. Buccione, G. Ziccheddu, F. Peschiaroli, P. Sestili, R. Puglisi, et al., Combining Type I Interferons and 5-Aza-2’-Deoxycitidine to Improve Anti-Tumor Response against Melanoma, J. Invest. Dermatol. 137 (2017) 159–169. doi:10.1016/j.jid.2016.08.024.

  21. M. Costantini, S. Testa, P. Mozetic, A. Barbetta, C. Fuoco, E. Fornetti, et al., Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo, Biomaterials. 131 (2017) 98–110. doi:10.1016/j.biomaterials.2017.03.026.

  22. M. Costantini, S. Testa, E. Fornetti, A. Barbetta, M. Trombetta, S.M. Cannata, et al., Engineering Muscle Networks in 3D Gelatin Methacryloyl Hydrogels: Influence of Mechanical Stiffness and Geometrical Confinement, Front. Bioeng. Biotechnol. 5 (2017) 22. doi:10.3389/fbioe.2017.00022.

  23. N. Celikkin, C. Rinoldi, M. Costantini, M. Trombetta, A. Rainer, W. Święszkowski, Naturally derived proteins and glycosaminoglycan scaffolds for tissue engineering applications, Mater. Sci. Eng. C. 78 (2017) 1277–1299. doi:10.1016/j.msec.2017.04.016.

  24. L. Tortora, S. Concolato, M. Urbini, S.M. Giannitelli, F. Basoli, A. Rainer, et al., Functionalization of poly(ε-caprolactone) surface with lactose-modified chitosan via alkaline hydrolysis: ToF-SIMS characterization, Biointerphases. 11 (2016) 02A323. doi:10.1116/1.4942498.

  25. C. Spadaccio, F. Nappi, F. De Marco, P. Sedati, F.W.H. Sutherland, M. Chello, et al., Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques, Drug Target Insights. 10 (2016) 1–7. doi:10.4137/DTI.S35202.

  26. C. Spadaccio, F. Nappi, N. Al-Attar, F.W. Sutherland, C. Acar, A. Nenna, et al., Old Myths, New Concerns: the Long-Term Effects of Ascending Aorta Replacement with Dacron Grafts. Not All That Glitters Is Gold, J. Cardiovasc. Transl. Res. 9 (2016) 334–42. doi:10.1007/s12265-016-9699-8.

  27. C. Spadaccio, P. Mozetic, F. Nappi, A. Nenna, F. Sutherland, M. Trombetta, et al., Cells and extracellular matrix interplay in cardiac valve disease: because age matters, Basic Res. Cardiol. 111 (2016) 16. doi:10.1007/s00395-016-0534-9.

  28. M. Gori, M.C. Simonelli, S.M. Giannitelli, L. Businaro, M. Trombetta, A. Rainer, Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device, PLoS One. 11 (2016) e0159729. doi:10.1371/journal.pone.0159729.

  29. A. Crescenzi, P. Trimboli, D.C. Modica, C. Taffon, L. Guidobaldi, S. Taccogna, et al., Preoperative Assessment of TERT Promoter Mutation on Thyroid Core Needle Biopsies Supports Diagnosis of Malignancy and Addresses Surgical Strategy, Horm. Metab. Res. 48 (2016) 157–62. doi:10.1055/s-0035-1548873.

  30. M. Costantini, C. Colosi, P. Mozetic, J. Jaroszewicz, A. Tosato, A. Rainer, et al., Correlation between porous texture and cell seeding efficiency of gas foaming and microfluidic foaming scaffolds, Mater. Sci. Eng. C. 62 (2016) 668–77. doi:10.1016/j.msec.2016.02.010.

  31. C. Spadaccio, A. Rainer, P. Mozetic, M. Trombetta, R.A. Dion, R. Barbato, et al., The role of extracellular matrix in age-related conduction disorders: a forgotten player?, J. Geriatr. Cardiol. 12 (2015) 76–82. doi:10.11909/j.issn.1671-5411.2015.01.009.

  32. R. Seyedmahmoud, A. Rainer, P. Mozetic, S. Maria Giannitelli, M. Trombetta, E. Traversa, et al., A primer of statistical methods for correlating parameters and properties of electrospun poly(L-lactide) scaffolds for tissue engineering--PART 1: design of experiments, J. Biomed. Mater. Res. A. 103 (2015) 91–102. doi:10.1002/jbm.a.35153.

  33. R. Seyedmahmoud, P. Mozetic, A. Rainer, S.M. Giannitelli, F. Basoli, M. Trombetta, et al., A primer of statistical methods for correlating parameters and properties of electrospun poly(L-lactide) scaffolds for tissue engineering--PART 2: regression, J. Biomed. Mater. Res. A. 103 (2015) 103–14. doi:10.1002/jbm.a.35183.

  34. D. Ribuffo, F. Lo Torto, S.M. Giannitelli, M. Urbini, L. Tortora, P. Mozetic, et al., The effect of post-mastectomy radiation therapy on breast implants: Unveiling biomaterial alterations with potential implications on capsular contracture, Mater. Sci. Eng. C. 57 (2015) 338–43. doi:10.1016/j.msec.2015.07.015.

  35. A.R. Perestrelo, A.C.P. Águas, A. Rainer, G. Forte, Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering, Sensors (Basel). 15 (2015) 31142–70. doi:10.3390/s151229848.

  36. B. Mecheri, D. De Porcellinis, P.T. Campana, A. Rainer, M. Trombetta, A. Marletta, et al., Tuning Structural Changes in Glucose Oxidase for Enzyme Fuel Cell Applications, ACS Appl. Mater. Interfaces. 7 (2015) 28311–8. doi:10.1021/acsami.5b08610.

  37. M. Gori, M. Trombetta, D. Santini, A. Rainer, Tissue engineering and microRNAs: future perspectives in regenerative medicine, Expert Opin. Biol. Ther. 15 (2015) 1601–22. doi:10.1517/14712598.2015.1071349.

  38. S.M. Giannitelli, P. Mozetic, M. Trombetta, A. Rainer, Combined additive manufacturing approaches in tissue engineering, Acta Biomater. 24 (2015) 1–11. doi:10.1016/j.actbio.2015.06.032.

  39. S.M. Giannitelli, F. Basoli, P. Mozetic, P. Piva, F.N. Bartuli, F. Luciani, et al., Graded porous polyurethane foam: a potential scaffold for oro-maxillary bone regeneration, Mater. Sci. Eng. C. 51 (2015) 329–35. doi:10.1016/j.msec.2015.03.002.

  40. C. Spadaccio, A. Rainer, R. Barbato, M. Trombetta, M. Chello, B. Meyns, The long-term follow up of large-diameter Dacron® vascular grafts in surgical practice: a review, J. Cardiovasc. Surg. (Torino). (2014). http://www.ncbi.nlm.nih.gov/pubmed/24727799 (accessed June 15, 2017).

  41. L. Ruzzini, F. Abbruzzese, A. Rainer, U.G. Longo, M. Trombetta, N. Maffulli, et al., Characterization of age-related changes of tendon stem cells from adult human tendons, Knee Surg. Sports Traumatol. Arthrosc. 22 (2014) 2856–66. doi:10.1007/s00167-013-2457-4.

  42. S.M. Giannitelli, D. Accoto, M. Trombetta, A. Rainer, Current trends in the design of scaffolds for computer-aided tissue engineering, Acta Biomater. 10 (2014) 580–94. doi:10.1016/j.actbio.2013.10.024.

  43. V. Chiono, P. Mozetic, M. Boffito, S. Sartori, E. Gioffredi, A. Silvestri, et al., Polyurethane-based scaffolds for myocardial tissue engineering, Interface Focus. 4 (2014) 20130045. doi:10.1098/rsfs.2013.0045.

  44. M. Catauro, F. Bollino, F. Papale, P. Mozetic, A. Rainer, M. Trombetta, Biological response of human mesenchymal stromal cells to titanium grade 4 implants coated with PCL/ZrO₂ hybrid materials synthesized by sol-gel route: in vitro evaluation, Mater. Sci. Eng. C. Mater. Biol. Appl. 45 (2014) 395–401. doi:10.1016/j.msec.2014.09.007.

  45. C. Spadaccio, A. Rainer, F. De Marco, M. Lusini, P. Gallo, P. Sedati, et al., In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium, Cell Transplant. 22 (2013) 493–503. doi:10.3727/096368912X652977.

  46. C. Spadaccio, A. Rainer, R. Barbato, M. Chello, B. Meyns, The fate of large-diameter Dacron® vascular grafts in surgical practice: are we really satisfied?, Int. J. Cardiol. 168 (2013) 5028–9. doi:10.1016/j.ijcard.2013.07.165.

  47. G.-M. Kim, K.H.T. Le, S.M. Giannitelli, Y.J. Lee, A. Rainer, M. Trombetta, Electrospinning of PCL/PVP blends for tissue engineering scaffolds, J. Mater. Sci. Mater. Med. 24 (2013) 1425–42. doi:10.1007/s10856-013-4893-6.

  48. M. Centola, F. Abbruzzese, C. Scotti, A. Barbero, G. Vadalà, V. Denaro, et al., Scaffold-based delivery of a clinically relevant anti-angiogenic drug promotes the formation of in vivo stable cartilage, Tissue Eng. Part A. 19 (2013) 1960–71. doi:10.1089/ten.TEA.2012.0455.

  49. M. Centola, F. Abbruzzese, C. Scotti, A. Barbero, G. Vadalà, V. Denaro, et al., Scaffold-Based Delivery of a Clinically Relevant Anti-Angiogenic Drug Promotes the Formation of In Vivo Stable Cartilage, Tissue Eng. Part A. 19 (2013) 1960–1971. doi:10.1089/ten.tea.2012.0455.

  50. D. Accoto, M.T. Francomano, A. Rainer, M. Trombetta, P.M. Rossini, E. Guglielmelli, An implantable neural interface with electromagnetic stimulation capabilities, Med. Hypotheses. 81 (2013) 322–7. doi:10.1016/j.mehy.2013.04.008.

  51. G. Vadalà, P. Mozetic, A. Rainer, M. Centola, M. Loppini, M. Trombetta, et al., Bioactive electrospun scaffold for annulus fibrosus repair and regeneration, Eur. Spine J. 21 Suppl 1 (2012) S20-6. doi:10.1007/s00586-012-2235-x.

  52. A. Rainer, S.M. Giannitelli, D. Accoto, S. De Porcellinis, E. Guglielmelli, M. Trombetta, Load-adaptive scaffold architecturing: a bioinspired approach to the design of porous additively manufactured scaffolds with optimized mechanical properties, Ann. Biomed. Eng. 40 (2012) 966–75. doi:10.1007/s10439-011-0465-4.

  53. M. Lusini, A. Di Martino, C. Spadaccio, A. Rainer, M. Chello, M. Fabbrocini, et al., Resynthesis of sternal dehiscence with autologous bone graft and autologous platelet gel, J. Wound Care. 21 (2012) 74, 76–7. doi:10.12968/jowc.2012.21.2.74.

  54. C. Spadaccio, A. Rainer, M. Trombetta, M. Centola, M. Lusini, M. Chello, et al., A G-CSF functionalized scaffold for stem cells seeding: a differentiating device for cardiac purposes, J. Cell. Mol. Med. 15 (2011) 1096–108. doi:10.1111/j.1582-4934.2010.01100.x.

  55. A. Rainer, C. Spadaccio, P. Sedati, F. De Marco, S. Carotti, M. Lusini, et al., Electrospun hydroxyapatite-functionalized PLLA scaffold: potential applications in sternal bone healing, Ann. Biomed. Eng. 39 (2011) 1882–90. doi:10.1007/s10439-011-0289-2.

  56. C. Spadaccio, A. Rainer, M. Centola, M. Trombetta, M. Chello, M. Lusini, et al., Heparin-releasing scaffold for stem cells: a differentiating device for vascular aims, Regen. Med. 5 (2010) 645–57. doi:10.2217/rme.10.25.

  57. A. Rainer, M. Centola, C. Spadaccio, G. Gherardi, J.A. Genovese, S. Licoccia, et al., Comparative study of different techniques for the sterilization of poly-L-lactide electrospun microfibers: effectiveness vs. material degradation, Int. J. Artif. Organs. 33 (2010) 76–85. http://www.ncbi.nlm.nih.gov/pubmed/20306434 (accessed June 15, 2017).

  58. M. Centola, A. Rainer, C. Spadaccio, S. De Porcellinis, J.A. Genovese, M. Trombetta, Combining electrospinning and fused deposition modeling for the fabrication of a hybrid vascular graft, Biofabrication. 2 (2010) 14102. doi:10.1088/1758-5082/2/1/014102.

  59. C. Spadaccio, A. Rainer, M. Trombetta, G. Vadalá, M. Chello, E. Covino, et al., Poly-L-lactic acid/hydroxyapatite electrospun nanocomposites induce chondrogenic differentiation of human MSC, Ann. Biomed. Eng. 37 (2009) 1376–89. doi:10.1007/s10439-009-9704-3.

  60. C. Spadaccio, M. Chello, M. Trombetta, A. Rainer, Y. Toyoda, J.A. Genovese, Drug releasing systems in cardiovascular tissue engineering, J. Cell. Mol. Med. 13 (2009) 422–39. doi:10.1111/j.1582-4934.2008.00532.x.

  61. A. Rainer, S.M. Giannitelli, F. Abbruzzese, E. Traversa, S. Licoccia, M. Trombetta, Fabrication of bioactive glass-ceramic foams mimicking human bone portions for regenerative medicine., Acta Biomater. 4 (2008) 362–9. doi:10.1016/j.actbio.2007.08.007.