We are working on the orthogonal chemical functionalization of colloidal nanoparticles (nanogels) through surface decoration with different moieties, based on peptide sequences or specific chemical groups, to promote the selective interaction with target cells. Indeed, the in vivo application of these biomaterials is strictly linked to their capability to selectively interact with specific inflamed, damaged or malignant cells, avoiding the immune response and the consequent undesired macrophage uptake.
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